Acute and subchronic toxicity studies in rodents generally report high LD values and no significant adverse effects at commonly used doses, indicating a wide safety margin
PMID: 141 WangLGongZZhangXZhuFLiuYJinCet al
A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-
Not surprisingly, the formulator called to say that they loved the texture, and the product had no odor